Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice.

نویسندگان

  • Ryan C Maves
  • Roger M Castillo Oré
  • Kevin R Porter
  • Tadeusz J Kochel
چکیده

We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 17 2  شماره 

صفحات  -

تاریخ انتشار 2010